We are biological creatures. We are born, we live, we die. There is no transcendent purpose to existence. At best we are creatures of reason, and by using reason we can cure ourselves of emotional excess. Purged of both hope and fear, we find courage in the face of helplessness, insignificance and uncertainty.

In this quote, Jonathan Sacks presents a view of human existence grounded in the reality of our biological nature. He acknowledges that we are biological creatures—we are born, we live, and we die—without a transcendent purpose beyond these basic facts of life. Sacks challenges the idea that life has an inherent or divine purpose, instead suggesting that humans are creatures of reason and that our understanding of the world comes through rational thinking rather than religious or metaphysical beliefs.

Sacks argues that by using reason, we can overcome the emotional extremes that often govern our lives. He suggests that emotional excess, driven by hope and fear, can cloud our judgment and prevent us from seeing life clearly. By applying reason to our emotional experiences, we can free ourselves from these powerful and often disruptive feelings. This rational approach allows us to confront the realities of helplessness, insignificance, and uncertainty without being overwhelmed by them.

The quote reflects a stoic philosophy, advocating for the idea that inner peace and courage come from accepting life as it is, rather than as we wish it to be. By purging ourselves of excessive emotions like hope and fear, we find a clearer and more balanced perspective. Sacks suggests that it is in the acceptance of life's inherent uncertainty and insignificance that we find true courage, not in clinging to hope for an idealized future or fearing what lies ahead.

Ultimately, Sacks’ words encourage a rational, grounded approach to life’s challenges. By recognizing the limitations of our biological existence and embracing reason over emotion, we can confront the difficulties of life with strength and clarity. This view empowers individuals to face the uncertainties of life without being controlled by irrational hopes or fears, finding courage in the acceptance of life's reality.