Denzel Washington has a great sense of humor. He did all those 'Nutty Professor' movies.

In this quote, Seth MacFarlane is highlighting the sense of humor of actor Denzel Washington, a portrayal that might seem surprising to some due to Washington's typically serious roles. MacFarlane’s comment about Washington doing the 'Nutty Professor' movies—comedy films starring Eddie Murphy—is likely a playful exaggeration or misstatement. Washington, known for his dramatic roles in films like Training Day and Malcolm X, has not appeared in those particular films, which adds a layer of humor to MacFarlane’s comment. It's an example of MacFarlane’s characteristic sarcasm and wit.

The mention of Denzel Washington in the context of comedy might also reflect the contrast between Washington’s established serious persona and the zany humor of movies like The Nutty Professor, which would create an amusing mental image for the audience. MacFarlane, known for his own brand of irreverent humor in shows like Family Guy, is likely using this juxtaposition to underscore the idea that humor can exist even in the most unexpected places, even for a serious actor like Washington.

By making this comment, MacFarlane could also be making a subtle point about how actors are often stereotyped into specific types of roles. Washington's comedic abilities, though not frequently showcased in mainstream films, might be underappreciated by the public. MacFarlane’s playful mention of the 'Nutty Professor' movies may imply that actors, no matter how dramatic or intense, can have a hidden, surprising side that involves humor.

The origin of this quote lies in MacFarlane’s often ironic and mocking style of humor. By making such an unexpected connection between a serious actor like Washington and a slapstick comedy series, MacFarlane pokes fun at the versatility that actors can have in different genres, using his own comedic lens to craft an amusing narrative.