In preparation for a career in academic medicine, I worked as a medical house officer at Columbia-Presbyterian Hospital from 1966 to 1968 and then joined Ira Pastan's laboratory at the National Institutes of Health as a Clinical Associate.

The quote by Harold E. Varmus, a Nobel Prize-winning scientist and former director of the National Institutes of Health (NIH), reflects on the early stages of his career in academic medicine. Varmus explains that he gained practical medical experience as a house officer at Columbia-Presbyterian Hospital from 1966 to 1968, which provided him with foundational clinical skills and exposure to patient care. This period laid the groundwork for his subsequent research career.

At its core, the quote highlights the integration of clinical training and scientific research in building a successful career in academic medicine. After his hospital work, Varmus joined Ira Pastan's laboratory at the NIH as a Clinical Associate, allowing him to apply his medical knowledge to pioneering biomedical research. This transition illustrates the close relationship between practical medicine and laboratory investigation.

The origin of the quote comes from Varmus reflecting on his professional trajectory and the experiences that shaped his contributions to molecular biology and cancer research. By sharing his early clinical and research positions, he emphasizes the importance of combining hands-on medical training with rigorous scientific inquiry to advance knowledge and patient care.

Ultimately, the quote serves as both a personal reflection and a broader lesson for aspiring physician-scientists. Varmus’ words demonstrate that a foundation in clinical medicine combined with opportunities in research laboratories is essential for developing expertise, contributing to scientific breakthroughs, and pursuing a career in academic medicine.

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